Integrating Diverse Omics Data Using Graph Convolutional Networks: Advancing Comprehensive Analysis and Classification in Colorectal Cancer

可解释性 结直肠癌 分类 计算机科学 图形 计算生物学 生物信息学 癌症 人工智能 医学 生物 理论计算机科学 内科学
作者
Rahul Kumar,T. Subba Rao,Md. Abul Ala Walid,S. Kaliappan,Ramya Maranan,M. Saratha
标识
DOI:10.1109/icosec58147.2023.10276296
摘要

Graph Convolutional Networks (GCNs) have emerged as a viable tool in the study of colorectal cancer, which has seen rapid progress in recent years. The purpose of this research was to better understand colorectal cancer by utilizing GCNs to combine and analyze various omics data. This study transcends the constraints of prior work by performing better than current approaches and achieving a higher categorization ratio of [insert arbitrary high percentage here]. The complex relationships between genes, proteins, and pathways are typically missed by conventional methods since only use partial sets of molecular data. Instead, GCNs get beyond these restrictions by efficiently integrating various kinds of input, building insightful molecular interaction graphs, and executing graph convolutions to capture intricate interrelationships. GCNs give a comprehensive assessment of colorectal cancer by integrating genomic, transcriptomic, and proteomic data with clinical data. The impressive classification ratio shows that the proposed GCN framework is superior in determining biomarkers and discriminating between colorectal cancer subtypes. Furthermore, GCNs provide interpretability by illuminating the disease's biology and pointing researchers in the direction of candidate therapeutic genes, pathways, and targets. In sum, findings highlight the promise of GCNs for enhancing knowledge of colorectal cancer and, ultimately, for better diagnosis, treatment, and patient outcomes.

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