In vivo and in silico anti-inflammatory properties of the sesquiterpene valencene

体内 卡拉胶 药理学 髓过氧化物酶 炎症 巴豆油 齐留顿 水肿 生物信息学 消炎药 化学 医学 花生四烯酸 免疫学 生物化学 花生四烯酸5-脂氧合酶 生物 内科学 生物技术 基因
作者
Lindaiane Bezerra Rodrigues,Isabel Sousa Alcântara,Cícero Pedro S. Júnior,Maria Rayane Correia de Oliveira,Anita O.B.P.B. Martins,Ticiano Magalhães Dantas,Jaime Ribeiro‐Filho,Henrique Douglas Melo Coutinho,Fabíolla Rocha Santos Passos,Lucindo José Quintans‐Júnior,Jackson Roberto Guedes da Silva Almeida,Natália Martins,Bonglee Kim,Irwin Rose Alencar de Menezes
出处
期刊:Biomedicine & Pharmacotherapy [Elsevier BV]
卷期号:153: 113478-113478 被引量:9
标识
DOI:10.1016/j.biopha.2022.113478
摘要

Valencene (VLN) is a sesquiterpene found in juices and essential oils of citrus species such as Cyperus rotundus. Considering the evidence that this species has anti-inflammatory effects, the present study aims to evaluate the anti-inflammatory activity of VLN in vivo and in silico. Swiss mice (n = 6) were orally treated according to their treatment groups as follows: VLN (10, 100 or 300 mg/kg), negative control (0.9% saline), and positive controls (indomethacin 25 mg/kg or promethazine 6 mg/kg). The anti-inflammatory activity was evaluated in murine models of acute and chronic inflammation. The inhibition of acute inflammation was evaluated in models of paw edema induced by different inflammatory agents (carrageenan, dextran, histamine, and arachidonic acid (AA)) and carrageenan-induced pleurisy and peritonitis. The modulation of chronic inflammation was evaluated in a granuloma model induced cotton pellets implantation. The interaction with inflammatory targets was evaluated in silico using molecular docking analysis. The administration of VLN to challenged mice significantly inhibited paw edema formation with no significant difference between the administered doses. The compound also reduced albumin extravasation, leukocyte recruitment, and the production of myeloperoxidase (MPO), IL-1β, and TNF-α in both pleural and peritoneal lavages. According to the mathematical-statistical model observed in silico analysis, this compound has favorable energy to interact with the cyclooxygenase enzyme (COX-2) and the histamine 1 (H1) receptor. Finally, animals treated with the sesquiterpene showed a reduction in both granuloma weight and concentration of total proteins in a chronic inflammation model. Given these findings, it is concluded that NLV presents promising pharmacological activity in murine models of acute and chronic inflammation.
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