高价分子
化学
炔基化
碘
试剂
烷氧基
激进的
组合化学
有机化学
催化作用
烷基
作者
Zhengyi Liu,Yue Pan,Peng Zou,Hanchu Huang,Yali Chen,Yiyun Chen
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-08-05
卷期号:24 (32): 5951-5956
被引量:9
标识
DOI:10.1021/acs.orglett.2c02210
摘要
Here we report δ-C-H alkynylation to synthesize various δ-alkynols from iminophenylacetic acids. The hypervalent iodine-coordinated benziodoxole-alkoxyl-iminophenylacetic acid complex was the key intermediate and was characterized by X-ray crystallography for the first time. δ-C-H alkynylation is compatible with sensitive functional groups, including azides, aldehydes, and free alcohols, for the synthesis of δ-alkynols with diversified substituents in excellent regioselectivity. This reaction extends to δ-hydroxylalkene and δ-hydroxylnitrile synthesis, and the δ-alkynol products are easily derivatized to other valuable bifunctional building blocks.
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