癌症
体内
纳米技术
医学
红细胞
药物输送
癌症治疗
癌细胞
药理学
材料科学
免疫学
内科学
生物
生物技术
作者
Siyu Wang,Yiwei Wang,Kai Jin,Bo Zhang,Shaojun Peng,Amit Kumar Nayak,Zhiqing Pang
标识
DOI:10.1080/17425247.2022.2108786
摘要
Introduction Red blood cell (or erythrocyte) membrane-camouflaged nanoparticles (RBC-NPs) not only have a superior circulation life and do not induce accelerated blood clearance but also possess special functions, which offers great potential in cancer therapy.Areas covered This review focuses on the recent advances of RBC-NPs for delivering various agents to treat cancers in light of their vital role in improving drug delivery. Meanwhile, the construction and in vivo behavior of RBC-NPs are discussed to provide an in-depth understanding of the basis of RBC-NPs for improved cancer drug delivery.Expert opinion Although RBC-NPs are quite prospective in delivering anti-cancer therapeutics, they are still in their infancy stage and many challenges need to be overcome for successful translation into the clinic. The preparation and modification of RBC membranes, the optimization of coating methods, the scale-up production and the quality control of RBC-NPs, and the drug loading and release should be carefully considered in the clinical translation of RBC-NPs for cancer therapy.
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