Frailty, an Independent Risk Factor in Progression Trajectory of Cardiometabolic Multimorbidity: A Prospective Study of UK Biobank

医学 危险系数 生命银行 冲程(发动机) 死因 内科学 糖尿病 多发病率 疾病 比例危险模型 前瞻性队列研究 2型糖尿病 老年学 置信区间 生物信息学 内分泌学 生物 机械工程 工程类
作者
Tianqi Ma,Lingfang He,Yi Luo,Dihan Fu,Jiaqi Huang,Guogang Zhang,Xunjie Cheng,Yongping Bai
出处
期刊:The Journals of Gerontology [Oxford University Press]
卷期号:78 (11): 2127-2135 被引量:7
标识
DOI:10.1093/gerona/glad125
摘要

Abstract Background Although frailty was associated with cardiometabolic diseases (CMDs, including coronary heart disease, stroke, and diabetes here), there was no systematic analyses estimating its role in incidence, progression, and prognosis of cardiometabolic multimorbidity (CMM). Methods We included 351 205 participants without CMDs at baseline in UK Biobank. Occurrences of first CMD, CMM, and death were recorded. We used multistate models to assess transition-specific role of baseline frailty measured by frailty phenotype and frailty index in CMM progression trajectory from no disease to single CMD, CMM, and death. Association between changes in frailty and outcomes was investigated among 17 264 participants. Results Among 351 205 participants (44.0% male, mean age 56.55 years), 8 190 (2.3%) had frail phenotype, and 13 615 (3.9%) were moderate/severe frail according to the frailty index. During median follow-up of 13.11 years, 41 558 participants experienced ≥1 CMD, 4 952 had CMM, and 20 670 died. In multistate models, frail phenotype-related hazard ratios were 1.94 and 2.69 for transitions from no CMD to single disease and death, 1.63 and 1.67 for transitions from single CMD to CMM and death, and 1.57 for transitions from CMM to death (all p < .001). Consistent results were observed for frailty index. Improvement of frailty reduced the risk of CMD progression and death. Conclusions Frailty is an independent risk factor for all transitions of CMM progression trajectory. Frailty-targeted management is a potential strategy for primary and secondary prevention of CMM beyond chronological age.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
mkW完成签到,获得积分10
1秒前
读研好难完成签到,获得积分10
1秒前
跳跃的罡发布了新的文献求助10
1秒前
论文侠完成签到 ,获得积分10
1秒前
神勇的雅香应助梓榆采纳,获得10
1秒前
1秒前
深情安青应助Mlwwq采纳,获得10
1秒前
脑洞疼应助耿强采纳,获得10
2秒前
江梦松完成签到,获得积分10
2秒前
2秒前
2秒前
liu发布了新的文献求助10
3秒前
4秒前
4秒前
水獭发布了新的文献求助10
5秒前
奥雷里亚诺的小金鱼完成签到,获得积分10
5秒前
5秒前
LZZ发布了新的文献求助10
5秒前
昵称发布了新的文献求助10
6秒前
认真的一刀发布了新的文献求助200
6秒前
Lin发布了新的文献求助10
6秒前
杨燕华完成签到,获得积分10
6秒前
pxy完成签到,获得积分10
7秒前
8秒前
8秒前
...完成签到,获得积分10
8秒前
tfsn20完成签到,获得积分0
8秒前
程程完成签到 ,获得积分10
8秒前
彪壮的明轩完成签到,获得积分10
8秒前
夏夏发布了新的文献求助10
9秒前
西子阳发布了新的文献求助10
9秒前
xf完成签到,获得积分10
9秒前
MrCoolWu发布了新的文献求助10
9秒前
qq应助zjudxn采纳,获得10
10秒前
10秒前
整齐的千万完成签到 ,获得积分10
10秒前
liu完成签到,获得积分10
11秒前
笨笨球发布了新的文献求助10
12秒前
14秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Social media impact on athlete mental health: #RealityCheck 1020
Ensartinib (Ensacove) for Non-Small Cell Lung Cancer 1000
Unseen Mendieta: The Unpublished Works of Ana Mendieta 1000
Bacterial collagenases and their clinical applications 800
El viaje de una vida: Memorias de María Lecea 800
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3527723
求助须知:如何正确求助?哪些是违规求助? 3107826
关于积分的说明 9286663
捐赠科研通 2805577
什么是DOI,文献DOI怎么找? 1539998
邀请新用户注册赠送积分活动 716878
科研通“疑难数据库(出版商)”最低求助积分说明 709762