A decellularized extracellular matrix derived from keratinocytes can suppress cellular senescence induced by replicative and oxidative stresses

Keratinocyte senescence is suppressed on a keratinocyte-derived decellularized ECM (dECM) through the increase of antioxidant activity. Keratinocyte function is also increased on this dECM, suggesting that this dECM is useful to establish epidermal models.