子痫前期
后代
胎盘
医学
内分泌学
内科学
内皮功能障碍
维生素D与神经学
血管内皮生长因子
发病机制
维生素D缺乏
骨化三醇受体
免疫印迹
莫里斯水上航行任务
怀孕
胎儿
免疫学
生物
海马体
遗传学
血管内皮生长因子受体
生物化学
基因
作者
Yantuanjin Ma,Yunxia Yang,Mengxin Lv,Yuhang Zhang,Qing He,Yaqin Zhang,Su Young Hong,Xingli Deng,Qing Yuan
出处
期刊:Placenta
[Elsevier]
日期:2022-12-01
卷期号:130: 34-41
被引量:6
标识
DOI:10.1016/j.placenta.2022.10.012
摘要
Accumulating epidemiological studies support that Vitamin D deficiency is associated with the pathogenesis of preeclampsia. However, it is unknown whether vitamin D can be used as a treatment for preeclampsia. This study aimed to explore whether vitamin D supplementation could improve the rat model of preeclampsia.LPS was used to establish a rat model of preeclampsia. Inflammatory cytokines were examined by QRT-PCR and ELISA assays, and the concentration of sfit-1 and NO was assessed by ELISA. Analyzing the pathological features of the placenta with hematoxylin-eosin. The spatial learning and memory abilities of offspring were evaluated by the Morris water maze. Immune histology and western blot were performed to evaluate the expression levels of inflammatory pathway-associated Factor and vascular endothelium-associated Factor in the placenta.Vitamin D treatment reduced the blood pressure and urine protein of PE model rats, alleviated pathological damage to the placenta and pregnancy outcomes, and protected PE offspring from impaired memory and learning abilities. Moreover, TLR4 signaling pathway in the placenta was inhibited. Furthermore, vitamin D supplementation increased the expression of endothelial growth factor and vascular relaxing factor, and there was no significant difference compared with the control group.We generated the result that Vitamin D supplementation significantly improved the phenotype of preeclampsia and adverse pregnancy outcome caused by an abnormal inflammatory reaction and endothelial dysfunction in the placenta, and improved the learning and cognitive ability of offspring.
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