[A retrospective controlled study of TACE-HAIC-targeted-immune quadruple therapy for intermediate and advanced-stage hepatocellular carcinoma].

医学 肝细胞癌 内科学 胃肠病学 阶段(地层学) 比例危险模型 联合疗法 对数秩检验 不利影响 肿瘤科 生存分析 入射(几何) 生物 光学 物理 古生物学
作者
L Li,Jiao He,Yuping Xie,X H Huang,Xiadi Weng,Xinting Pan,Yubin Jiao,Hou-bing Zheng,Luzhen Qiu,Wanping Guo
出处
期刊:PubMed 卷期号:30 (9): 939-946
标识
DOI:10.3760/cma.j.cn501113-20220823-00432
摘要

Objective: To evaluate the efficacy and safety of transcatheter arterial chemoembolization (TACE)-hepatic arterial infusion chemotherapy (HAIC)-targeted-immune quadruple therapy in patients with intermediate and advanced-stage hepatocellular carcinoma (HCC). Methods: 101 patients with intermediate and advanced stage HCC were enrolled according to the inclusion and exclusion criteria, and then they were divided into a combination group and a control group. Patients in the combination group was treated with TACE-HAIC-targeted-immune quadruple therapy, while the control group was only treated with TACE therapy. The overall survival (OS), progression-free survival (PFS), and treatment-related adverse reactions were statistically analyzed in the two groups of patients. Statistical analysis was carried out by t-test, χ2 test, rank sum test, Kaplan-Meier curve, log-rank test, Cox regression (or proportional hazards model) analysis according to different data. Results: The tumor objective response rate and disease control rate as evaluated by mRECIST 1.1 criteria in the combination group were 80% and 94%, respectively, which were significantly higher than those in the control group, 41.2% (P<0.001) and 74.5% (P=0.007). The OS and PFS of the combination group were 15.6 months [95%CI 11.3-NA ] and 8.8 months [95%CI 6.9-12.0], respectively, which were significantly better than the control group at 6.1 months [95%CI 5.3-6.6] (P<0.001) and 3.2 months [95%CI 3.0-3.6] (P<0.001). Gastric ulcer incidence was significantly higher in the combination group (9/50, 18%) than that in the control group (2/51, 3.9%) (P=0.023). Conclusion TACE-HAIC-targeted-immune quadruple therapy is a more effective treatment mode for intermediate and advanced-stage HCC than TACE alone, and attention should be paid to the monitoring of target immune-related adverse reactions.目的: 评价经导管动脉化疗栓塞术(TACE)-肝动脉灌注化疗(HAIC)-靶向-免疫四联治疗中晚期肝细胞癌(HCC)患者的疗效和安全性。 方法: 根据入排标准入组101例中晚期HCC患者,分为联合组和对照组。联合组患者行TACE-HAIC-靶向-免疫四联治疗,对照组患者仅接受TACE治疗。对2组患者的总生存期(OS)、无疾病进展生存期(PFS)、治疗相关的不良反应进行统计分析。据资料不同采用t检验、χ2检验、秩和检验、Kaplan-Meier曲线、对数秩检验、Cox回归分析或Cox比例风险模型分析进行统计学分析。 结果: 以mRECIST 1.1标准评估联合组肿瘤客观缓解率和疾病控制率分别为80%和94%,明显高于对照组的41.2%(P<0.001)和74.5%(P=0.007)。联合组的OS和PFS为15.6(95%CI 11.3~NA)个月和8.8(95%CI 6.9~12.0)个月,明显优于对照组的6.1(95%CI 5.3~6.6)个月(P<0.001)和3.2(95%CI 3.0~3.6)个月(P<0.001)。联合组胃溃疡发生率(9/50,18%)比对照组(2/51,3.9%)明显增加(P=0.023)。 结论: TACE-HAIC-靶向-免疫四联治疗对比单纯TACE治疗是一种更有效的中晚期HCC治疗方式,需注意对靶免治疗相关不良反应的监测。.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
王安琪发布了新的文献求助10
1秒前
Caliho完成签到,获得积分10
1秒前
ky小白白完成签到 ,获得积分10
3秒前
6秒前
鼹鼠发布了新的文献求助10
6秒前
8秒前
迅速戒指完成签到 ,获得积分10
9秒前
doubleshake发布了新的文献求助10
13秒前
13秒前
玖念发布了新的文献求助10
13秒前
15秒前
傅朝西完成签到,获得积分10
15秒前
劲秉应助doubleshake采纳,获得30
18秒前
脑洞疼应助doubleshake采纳,获得10
18秒前
19秒前
桐桐应助小何同学采纳,获得10
26秒前
咩咩羊给咩咩羊的求助进行了留言
27秒前
彭于晏应助不喝可乐采纳,获得10
27秒前
28秒前
852应助跟屁虫采纳,获得10
31秒前
muncy发布了新的文献求助10
33秒前
34秒前
35秒前
37秒前
37秒前
鼹鼠完成签到 ,获得积分20
37秒前
38秒前
六七完成签到,获得积分10
38秒前
WYP发布了新的文献求助10
40秒前
41秒前
z12发布了新的文献求助30
42秒前
Roxan完成签到,获得积分20
42秒前
科研通AI2S应助Aggie采纳,获得10
42秒前
42秒前
瑞仔发布了新的文献求助10
43秒前
43秒前
44秒前
小二郎应助武雨寒采纳,获得10
44秒前
Hello应助WYP采纳,获得10
45秒前
46秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
安全防范技术与工程 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A real-time energy management strategy based on fuzzy control and ECMS for PHEVs 400
2024 Medicinal Chemistry Reviews 400
Актуализированная стратиграфическая схема триасовых отложений Прикаспийского региона. Объяснительная записка 360
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3191522
求助须知:如何正确求助?哪些是违规求助? 2840870
关于积分的说明 8030544
捐赠科研通 2504273
什么是DOI,文献DOI怎么找? 1337556
科研通“疑难数据库(出版商)”最低求助积分说明 638130
邀请新用户注册赠送积分活动 606663