一氧化氮
炎症
一氧化氮合酶
酶
信号转导
疾病
生物
化学
细胞生物学
癌症研究
免疫学
生物化学
医学
内科学
内分泌学
作者
Katrina M. Miranda,Lisa A. Ridnour,Robert Cheng,David A. Wink,Douglas D. Thomas
标识
DOI:10.1615/critrevoncog.2023047302
摘要
Nitric oxide (NO) and the enzyme that synthesizes it, nitric oxide synthase 2 (NOS2), have emerged as key players in inflammation and cancer. Expression of NOS2 in tumors has been correlated both with positive outcomes and with poor prognoses. The chemistry of NO is the major determinate to the biological outcome and the concentration of NO, which can range over five orders of magnitude, is critical in determining which pathways are activated. It is the activation of specific oncogenic and immunological mechanisms that shape the outcome. The kinetics of specific reactions determine the mechanisms of action. In this review, the relevant reactions of NO and related species are discussed with respect to these oncogenic and immunological signals.
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