纳米纤维
材料科学
神经干细胞
神经组织工程
纳米技术
干细胞
轴突
生长锥
组织工程
生物物理学
生物医学工程
细胞生物学
生物
医学
作者
Xiaopei Zhang,Mingxia Guo,Qingxia Guo,Na Liu,Yuanfei Wang,Tong Wu
标识
DOI:10.1016/j.mtadv.2023.100343
摘要
In tissue repair, cell behaviors can be modulated by sensing and responding to the topographical and biochemical cues provided by the surrounding microenvironment. Herein, we designed and fabricated a class of uniaxially aligned nanofiber yarns welded with electrosprayed microparticles to guide the directional growth of axons and the migration of neural stem cells. By tuning the depositing density of microparticles on the nanofiber yarns, the surface roughness was varied, which facilitated the directional axon outgrowth of PC12 and SH-SY5Y cells and the alignment of Schwann cells. The microparticles were further modified by loading nerve growth factors in the core and then deposited on the nanofiber yarns. Owing to the synthetic effects provided by the physical and biological signals, the migration of neural stem cells was significantly accelerated. Taken together, the uniaxially aligned nanofiber yarns welded by functionalized microparticles show promising use in manipulating axonal growth and the migration of neural stem cells, which will provide a novel approach to clinical repair of nerve injuries.
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