清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

A Long-Lasting Triamcinolone-Loaded Microneedle Patch for Prolonged Dermal Delivery

曲安奈德 差示扫描量热法 材料科学 生物医学工程 傅里叶变换红外光谱 聚乳酸 渗透 透皮 医学 复合材料 外科 化学 聚合物 化学工程 药理学 工程类 生物化学 物理 热力学
作者
Nasrin Zarei Chamgordani,Sasan Asiaei,Fatemeh Ghorbani‐Bidkorbeh,Masoud Babaee Foroutan,Mostafa Dahmardehei,Hamid Reza Moghimi
标识
DOI:10.5812/ijpr-138857
摘要

Background: Scar is an unpleasant skin lesion that occurs following deep wounds or burns. The application of local triamcinolone is a common treatment for scar treatment and prevention, which should be repeated several times in conventional dosage forms. An effort has been made here to provide a prolonged triamcinolone dermal delivery by microneedle technology, which can also be used for wound closure. Objectives: This study aimed to develop a long-lasting polylactic acid (PLA) microneedle patch for the prolonged release of triamcinolone acetonide (TrA) that could potentially be used for closure of wound edges and scar prevention and treatment. Methods: In this study, 3% and 10% TrA-containing polymeric microneedles were fabricated using the micro molding-solvent casting method. Optical microscopy, X-ray diffraction analysis (XRD), Fourier-transform infrared spectroscopy (FT-IR), and differential scanning calorimetry (DSC) were used for the characterization of microneedles. Mechanical strength was evaluated using a compression test and methylene blue staining. Additionally, the insertion depth was determined by histopathological sectioning of human skin samples and also insertion into Parafilm®M as a skin model. The in vitro drug release profile of the microneedles was studied over 34 days, and the kinetic model was determined. The ex-vivo skin permeation of TrA was studied using a Franz-diffusion cell. Results: The TrA-containing PLA microneedles were fabricated with a uniform structure without any failure, deterioration, or loss of needles. Fourier-transform infrared spectroscopy and differential scanning calorimetry showed no interaction between TrA and PLA, and no effect on crystallinity and thermal behavior of TrA on polymer was detected. Microneedles showed appropriate mechanical properties, which were able to penetrate to about 900 - 1000 μm depth. Release profile from the whole body of 10% and 3% microneedle fitted to Higuchi model with cumulative amounts of 625 µg and 201.64 µg over 34 days. Release from the needles followed zero-order kinetic with cumulative amounts of 30.04 µg and 20.36 µg for 10% and 3%, respectively, for 34 days. Permeation was calculated to be 17 µg/day for 10% TrA-containing microneedle. Conclusions: The results suggested that suitable PLA microneedles containing TrA with prolonged release behavior can be successfully constructed with the solvent casting method.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Zoe完成签到 ,获得积分10
7秒前
TAO LEE完成签到 ,获得积分10
12秒前
NexusExplorer应助科研通管家采纳,获得10
31秒前
小白完成签到 ,获得积分10
42秒前
haha完成签到 ,获得积分10
51秒前
海派Hi完成签到 ,获得积分10
57秒前
1分钟前
WIS完成签到,获得积分10
1分钟前
WIS发布了新的文献求助10
1分钟前
应夏山完成签到 ,获得积分10
1分钟前
borisgugugugu完成签到,获得积分10
1分钟前
wyt完成签到,获得积分10
1分钟前
住在魔仙堡的鱼完成签到 ,获得积分10
3分钟前
yuntong完成签到 ,获得积分10
3分钟前
精明寒松完成签到 ,获得积分10
3分钟前
三跳完成签到 ,获得积分10
3分钟前
Wang完成签到 ,获得积分20
3分钟前
研友_Z119gZ完成签到 ,获得积分10
3分钟前
Aray完成签到 ,获得积分10
4分钟前
4分钟前
Gab_bb发布了新的文献求助10
4分钟前
一个小胖子完成签到,获得积分10
4分钟前
科研通AI2S应助科研通管家采纳,获得10
4分钟前
嗯嗯嗯哦哦哦完成签到 ,获得积分10
5分钟前
Whisper完成签到 ,获得积分10
5分钟前
vbnn完成签到 ,获得积分10
5分钟前
快乐元菱完成签到 ,获得积分10
5分钟前
Eric800824完成签到 ,获得积分10
5分钟前
平常山河完成签到 ,获得积分10
5分钟前
aiyawy完成签到 ,获得积分10
6分钟前
咯咯咯完成签到 ,获得积分10
7分钟前
研友_ZbP41L完成签到 ,获得积分10
7分钟前
7分钟前
fogsea完成签到,获得积分0
7分钟前
康2000发布了新的文献求助10
7分钟前
Yanice_Wan完成签到 ,获得积分10
7分钟前
周小浪完成签到,获得积分10
8分钟前
kenchilie完成签到 ,获得积分10
9分钟前
Somnus完成签到 ,获得积分10
9分钟前
雪花完成签到 ,获得积分10
9分钟前
高分求助中
Evolution 10000
Distribution Dependent Stochastic Differential Equations 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 500
Die Gottesanbeterin: Mantis religiosa: 656 400
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3158657
求助须知:如何正确求助?哪些是违规求助? 2809828
关于积分的说明 7883729
捐赠科研通 2468521
什么是DOI,文献DOI怎么找? 1314297
科研通“疑难数据库(出版商)”最低求助积分说明 630582
版权声明 601983