免疫监视
杂合子丢失
人类白细胞抗原
肺癌
等位基因
遗传学
人口
免疫学
医学
癌症
癌症研究
生物
肿瘤科
基因
抗原
环境卫生
作者
Chirag Krishna,Anniina Tervi,Miriam Saffern,E. A. Wilson,Seong‐Keun Yoo,Nina Mars,Vladimir Roudko,Byuri Angela Cho,Samuel E. Jones,Natalie Vaninov,Myvizhi Esai Selvan,Zeynep H. Gümüş,Tobias L. Lenz,Miriam Mérad,Paolo Boffetta,Francisco Martínez-Jiménez,Hanna M. Ollila,Robert M. Samstein,Diego Chowell
出处
期刊：Science
[American Association for the Advancement of Science]
日期：2024-02-22
卷期号：383 (6685)
被引量：12
标识
DOI：10.1126/science.adi3808
摘要
Cancer risk is influenced by inherited mutations, DNA replication errors, and environmental factors. However, the influence of genetic variation in immunosurveillance on cancer risk is not well understood. Leveraging population-level data from the UK Biobank and FinnGen, we show that heterozygosity at the
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