'Environmental standard limit concentration' arsenic exposure is associated with anxiety, depression, and autism-like changes in early-life stage zebrafish

斑马鱼 自闭症 焦虑 萧条(经济学) 少年 生理学 心理学 生物 化学 精神科 遗传学 基因 宏观经济学 经济 有机化学
作者
Yuanhui Zhu,Qianlei Yang,Jie Gu,Zhicheng Chen,Jing Nan,Tingxu Jin,Jiayuan Lin,Xin Wang,Jingwen Hu,Guixiang Ji,Yan An
出处
期刊:Journal of Hazardous Materials [Elsevier BV]
卷期号:469: 133953-133953 被引量:10
标识
DOI:10.1016/j.jhazmat.2024.133953
摘要

Arsenic is a worldwide environmental pollutant that can impair human health. Previous studies have identified mental disorders induced by arsenic, but the environmental exposure concentrations in the early life stages associated with these disorders are poorly understood. In the present study, early-life stage zebrafish were used to explore the effects on mental disorders under 'environmental standard limit concentrations' arsenic exposures of 5, 10, 50, 150, and 500 μg/L. The results showed that arsenic exposure at these concentrations changed the locomotor behavior in larval zebrafish and was further associated with anxiety, depression, and autism-like behavior in both larval and juvenile zebrafish. Changes were noted at benchmark dose limit (BMDL) concentrations as low as 0.81 μg/L. Transcriptomics showed that immediate early genes (IEGs) fosab, egr1, egr2a, ier2b, egr3, and jund were decreased after arsenic exposure in larval and juvenile zebrafish. Nervous system impairment and anxiety, depression, and autism-like behaviors in early-life stage zebrafish at 'environmental standard limit concentrations' may be attributed to the downregulation of IEGs. These findings in zebrafish provided new experimental support for an arsenic toxicity threshold for mental disorders, and they suggest that low levels of environmental chemicals may be causative developmental factors for mental disorders.
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