夜蛾科
黄原酮
藤黄属
立体化学
化学
植物化学
细胞毒性
细胞培养
联苯
细胞毒性T细胞
生药学
生物活性
生物
体外
生物化学
植物
有机化学
遗传学
作者
Ayano Kobayashi,Yohei Saito,Katsunori Miyake,Shuichi Fukuyoshi,David Newman,Barry R. O’Keefe,Kuo‐Hsiung Lee,Kyoko Nakagawa‐Goto
标识
DOI:10.1021/acs.jnatprod.3c00934
摘要
Four cytotoxic heptacyclic caged-xanthones [gambogefic acids B–E (1–4)], a cytotoxic hexacyclic caged-xanthone [garcilatelic acid (5)], and four biphenyl derivatives [garcilatelibiphenyls A–D (6–9)] were newly isolated in a phytochemical study of a 50% MeOH/CH2Cl2 extract of Garcinia lateriflora (Clusiaceae). The isolated compounds were evaluated for antiproliferative activity against five human tumor cell lines including a vincristine-resistant line. The new caged-xanthones displayed potent activity with IC50 values from 0.5 to 6.7 μM against all tested tumor cell lines.
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