Biomonitoring and risk assessment of human exposure to triazole fungicides

生物监测 杀虫剂 尿 毒理 丙二醛 医学 风险评估 危险系数 生理学 氧化应激 环境卫生 化学 生物 健康风险 内科学 环境化学 计算机安全 计算机科学 农学
作者
Luiz Paulo de Aguiar Marciano,Luiz Francisco Machado da Costa,Naiane Silva Cardoso,Josiane Oliveira Freire,Fernando Feltrim,Geovana Sousa Oliveira,Fernanda Borges de Araújo Paula,Alessandra C.P. Silvério,Isarita Martins
出处
期刊:Regulatory Toxicology and Pharmacology [Elsevier BV]
卷期号:147: 105565-105565 被引量:6
标识
DOI:10.1016/j.yrtph.2024.105565
摘要

Risk assessment and biomarkers were evaluated in volunteers exposed to triazole fungicides in southern Minas Gerais, Brazil. Volunteers were divided into two groups: occupationally and environmentally exposed to pesticides (n = 140) and those unexposed (n = 50) from urban areas. Urine samples were analyzed by GC-MS for triazoles, and samples from men and women in the exposed group were quantified. Groups were further stratified by sex to evaluate the biomarkers results. Oxidative stress was indicated by biomarker analysis for occupationally exposed men with elevated malondialdehyde levels and reduced superoxide dismutase and catalase activity (p < 0.0001). Bile acid levels were also elevated in the exposed group (p < 0.0001). Biomarkers in this study suggest recent, reversible changes due to pesticide exposure. Liver enzyme levels showed no significant differences. The highest Estimated Daily Intake for epoxiconazole ranged from 0.534 to 6.31 μg/kg-bw/day for men and 0.657–8.77 μg/kg-bw/day for women in the exposed group. Considering the highest detected urinary triazole value, the calculated Hazard Quotient for epoxiconazole was 0.789 for men and 1.1 for women. Results indicate a health risk associated with environmental triazole exposure, highlighting the importance of biomonitoring in risk assessment to prevent intoxication and assist in mitigating adverse health effects from chronic pesticide exposure.
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