对映选择合成
炔丙基
三氟甲基
亲脂性
催化作用
化学
铜
有机化学
组合化学
烷基
作者
Yangdong Hou,Zhang Zhang,Xinyu Sun,Zheng Yang,Yu‐Xin Luan,Pingping Tang
标识
DOI:10.1002/anie.202218919
摘要
Due to the strong electron-withdrawing nature and high lipophilicity of trifluoromethoxy group (OCF3 ), methods for introducing OCF3 into organic molecules are in high demand. However, the research area of direct enantioselective trifluoromethoxylation is still in the embryonic stage, with limited enantioselectivity and/or reaction types. Here, we describe the first copper-catalyzed enantioselective trifluoromethoxylation of propargyl sulfonates using trifluoromethyl arylsulfonate (TFMS) as the trifluoromethoxy source in up to 96 % ee.
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