化学
电泳剂
区域选择性
产量(工程)
锌
组合化学
俘获
氯化物
表面改性
有机化学
催化作用
生态学
生物
物理化学
冶金
材料科学
作者
Yuxuan Feng,Taro Yukioka,Mei Matsuyama,Atsunori Mori,Kentaro Okano
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-04-21
卷期号:25 (17): 3013-3017
被引量:9
标识
DOI:10.1021/acs.orglett.3c00800
摘要
A method for the regioselective functionalization of haloarenes through deprotonative lithiation is disclosed. The generated haloaryllithiums were trapped in a batch reactor with a zinc chloride diamine complex to provide organozinc species without aryne formation, which reacted with electrophiles to afford the corresponding products in 38-98% yields. This method was applied to the five-step total synthesis of carbazomycin A on a gram scale in 33% overall yield.
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