Exploration at the network pharmacology level of possible targeting mechanisms of Smilacis Glabrae Rhixoma for the treatment of osteoporosis.

骨质疏松症 药理学 破骨细胞 机制(生物学) 医学 生物信息学 内科学 生物 受体 认识论 哲学
作者
B-W Lu,X-Z Liang,M-T Wen,G Li
出处
期刊:PubMed 卷期号:27 (8): 3681-3698
标识
DOI:10.26355/eurrev_202304_32165
摘要

The aim of this study was to evaluate the therapeutic effect of Smilacis Glabrae Rhixoma (SGR) on osteoporosis at the level of network pharmacology, and to find new targets and mechanisms of SGR in the treatment of osteoporosis, to better find new drugs and their clinical applications.In the original network pharmacology mode, we used an improved mode, such as screening the ingredients and targets of SGR through tools such as GEO database, Autodock Vina, and GROMACS. Through molecular docking, we conducted further screening for the targets acting on the effective ingredients of SGR, and finally we performed molecular dynamics simulation and consulted a large amount of related literature for the validation of the results.By screening and validating the data, we finally confirmed that there were mainly 10 active ingredients in SGR, which were isoeruboside b, smilagenin, diosgenin, stigmasterol, beta-sitosterol, sodium taurocholate, sitogluside, 4,7-dihydroxy-5-methoxy-6-methyl-8-formyl-flavan, simiglaside B, and simiglaside E, and mainly acted on eleven targets. These targets mainly exert therapeutic effects on osteoporosis by regulating 20 signaling pathways including Th17 cell differentiation, HIF-1 signaling pathway, apoptosis, inflammatory bowel disease, and osteoclast differentiation.Our study successfully explains the effective mechanism by which SGR ameliorates osteoporosis while predicting the potential targets NFKB1 and CTSK of SGR for the treatment of osteoporosis, which provides a novel basis for investigating the mechanism of action of new Traditional Chinese medicines (TCMs) at the network pharmacology level and a great support for subsequent studies on osteoporosis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
3秒前
4秒前
fifteen发布了新的文献求助10
5秒前
5秒前
6秒前
6秒前
坚强亦丝应助科研通管家采纳,获得10
6秒前
JamesPei应助科研通管家采纳,获得10
6秒前
7秒前
英俊的铭应助科研通管家采纳,获得10
7秒前
英俊的铭应助科研通管家采纳,获得10
7秒前
认真的傲柏完成签到,获得积分20
7秒前
852应助科研通管家采纳,获得10
7秒前
赘婿应助科研通管家采纳,获得10
7秒前
坚强亦丝应助科研通管家采纳,获得10
7秒前
SciGPT应助科研通管家采纳,获得30
7秒前
7秒前
Ava应助科研通管家采纳,获得10
7秒前
7秒前
7秒前
7秒前
九三发布了新的文献求助10
8秒前
顾矜应助要减肥的语堂采纳,获得10
9秒前
jj发布了新的文献求助10
10秒前
满天星完成签到,获得积分10
10秒前
ZD完成签到 ,获得积分10
11秒前
撒西不理完成签到,获得积分10
11秒前
12秒前
12秒前
冷酷的松思完成签到,获得积分10
14秒前
科研的神完成签到,获得积分20
14秒前
15秒前
去去去去发布了新的文献求助10
18秒前
in完成签到,获得积分20
18秒前
务实的又柔完成签到,获得积分10
19秒前
万能图书馆应助不想起采纳,获得10
19秒前
乐乐应助jj采纳,获得10
22秒前
旧城旧巷等旧人完成签到 ,获得积分10
23秒前
24秒前
高分求助中
Evolution 10000
ISSN 2159-8274 EISSN 2159-8290 1000
Becoming: An Introduction to Jung's Concept of Individuation 600
Ore genesis in the Zambian Copperbelt with particular reference to the northern sector of the Chambishi basin 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3163383
求助须知:如何正确求助?哪些是违规求助? 2814219
关于积分的说明 7903906
捐赠科研通 2473789
什么是DOI,文献DOI怎么找? 1317077
科研通“疑难数据库(出版商)”最低求助积分说明 631615
版权声明 602187