化学
工作流程
共价键
DNA
计算生物学
组合化学
生物化学
数据库
计算机科学
有机化学
生物
作者
Xudong Wang,Liwei Xiong,Ying Zhu,Sixiu Liu,Wenfeng Zhao,Xinyuan Wu,Mengnisa Seydimemet,Linjie Li,Peng Ding,Xian Lin,Jiaxiang Liu,Xuan Wang,Zhiqiang Duan,Weiwei Lu,Yanrui Suo,Mengqing Cui,Jinfeng Yue,Rui Jin,Mingyue Zheng,Yechun Xu,Lianghe Mei,Hangchen Hu,Xiaojie Lu
摘要
The COVID-19 pandemic, exacerbated by persistent viral mutations, underscored the urgent need for diverse inhibitors targeting multiple viral proteins. In this study, we utilized covalent DNA-encoded libraries to discover innovative triazine-based covalent inhibitors for the 3-chymotrypsin-like protease (3CL
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