Autologous Platelet-rich Plasma for the Treatment of Nonhealing Perineal Wounds: A Report of Two Cases

Patients with perineal wounds often encounter difficulty in local wound healing after hemorrhoidectomies. PRP contains a high concentration of platelets and has been used to improve wound healing.In this case study, PRP was used in the treatment of nonhealing perineal wounds to expedite wound healing.The 2 patients in these cases suffered from perineal wounds that were nonhealing for more than 2 months. After assessment of their physical condition, autologous PRP was used in the treatment of both patients. A total of 150 mL of peripheral blood was collected from each patient to prepare autologous PRP in a completely enclosed environment. For one patient, the PRP product was injected subcutaneously around the wound. The rest of the PRP product was activated into a gel by thrombin and calcium chloride, and the gel was applied to the surface of the wound with dressing changes every 5 days. The other patient was externally treated with autologous PRP gel, and dressing changes were administered after a week. The 2 patients were treated twice with PRP, and both completely recovered within 2 weeks without any other treatment.As an autologous blood-derived product, PRP was safe and showed promising results in perineal wound healing.