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Real-world analysis of cost, treatment patterns, and outcomes of patients with metastatic cutaneous squamous cell carcinoma in the US

医学 西妥昔单抗 内科学 卡铂 放射治疗 肿瘤科 化疗 顺铂 回顾性队列研究 癌症 结直肠癌
作者
Xue Song,Chieh-I Chen,Gerasimos Konidaris,Nicole M. Zimmerman,Emily Ruiz
出处
期刊:Expert Review of Pharmacoeconomics & Outcomes Research [Taylor & Francis]
卷期号:: 1-10
标识
DOI:10.1080/14737167.2023.2223982
摘要

Objectives To describe real-world characteristics and treatment patterns of patients with metastatic cutaneous squamous cell carcinoma (mCSCC).Methods This retrospective observational study used MarketScan Commercial and Medicare Supplemental claims databases (1/1/2013–7/31/2019). Adult patients with mCSCC who initiated non-immunotherapy systemic treatment (i.e. index event) between 1 January 2014 and 31 December 2018 were assessed for treatment patterns, all-cause and CSCC-related healthcare resource utilization, costs, and mortality .Results Overall, 207 patients were included in the study(mean age 64.8 years, 76.3% male), 59.4% had prior radiotherapy, and 58.9% had prior CSCC-related surgery. During follow-up, 75.8%, 51.7%, and 35.7% of patients received chemotherapy, radiotherapy, and targeted therapy as first-line treatment, respectively. Cisplatin (32.9%) and carboplatin (22.7%) were the most common chemotherapy agents, and cetuximab (32.4%) was the most common targeted therapy during the first-line.Probability of death (95% CI) at month 6, year 1, and year 2 was 24% (16–32%), 50% (40 − 59%), and 67% (56 − 75%), respectively. Average CSCC-related healthcare costs were $5,354 per person per month (PPPM), with outpatient costs being the major cost driver at 96.4% ($5,160 PPPM).Conclusion During 2014–2018, patients with mCSCC were commonly treated with cisplatin and cetuximab; prognosis was generally poor. These results indicate opportunity for new treatments to improve survival outcomes.
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