H2S-activated fluorescent probe enables dual-channel fluorescence tracking of drug release in tumor cells

化学 荧光 克里唑蒂尼 生物物理学 癌细胞 药品 癌症研究 癌症 肺癌 药理学 病理 物理 恶性胸腔积液 生物 医学 量子力学 遗传学
作者
Caiyun Liu,Yan Zhang,Weimin Sun,Hanchuang Zhu,Meijun Su,Xin Wang,Xiaodi Rong,Kun Wang,Miaohui Yu,Wenlong Sheng,Baocun Zhu
出处
期刊:Bioorganic Chemistry [Elsevier BV]
卷期号:135: 106498-106498 被引量:9
标识
DOI:10.1016/j.bioorg.2023.106498
摘要

Nowadays, the selective release of therapeutic drugs into tumor cells has become an important way of tumor treatment due to the high side effects of chemotherapy drugs. As one of the gas mediators, hydrogen sulfide (H2S) is closely related to cancer. Due to the high content of H2S in tumor cells, it can be used as a signaling molecule that triggers the release of drugs to achieve the selective release of therapeutic drugs. In addition, dual-channel fluorescence imaging technology can be better applied to monitor the drug delivery process and distinguish the state before and after drug release, so as to better track the effect of drug therapy. Based on this, we used NBD amines (NBD-NHR) as the recognition group of H2S and connected the tyrosine kinase inhibitor crizotinib to construct an activated dual-channel fluorescent probe CZ-NBD. After the probe enters the tumor cells, it consumes H2S and releases crizotinib, which is highly toxic to the tumor cells. Importantly, the probe displays significant fluorescence changes in different cells, enabling not only the screening of tumor cells, but also tracking and monitoring drug release and tumor cell activity. Therefore, the construction of probe CZ-NBD provides a new strategy for drug release monitoring in tumor cells.
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