Copper-Catalyzed Radical Addition of Alkynols to Synthesize Difluoroheterocyclic Compounds

A convenient method for the synthesis of fluorine-containing heterocyclic compounds was developed by a copper-catalyzed free radical addition reaction of alkynol and ethyl bromodifluoroacetate. This strategy involves copper-catalyzed free radical addition and molecular lactone exchange of ethynyl alcohol and ethyl bromodifluoroacetate. The method is characterized by easy availability of raw materials, good stereochemical selectivity, and simple operation. More importantly, valuable tetrasubstituted E-configurated alkenes and various vinyl C-Br bonds and difluoromethylene-containing functionalized heterocycles can be obtained by this method.