手性(物理)
化学
圆二色性
对映体
烷基
轴手性
共价键
对映选择合成
动态共价化学
超分子手性
芳基
有机化学
立体化学
分子
催化作用
超分子化学
物理
手征对称破缺
量子力学
Nambu–Jona Lasinio模型
夸克
作者
Guoshan Jiang,Lifeng Wang,Hebo Ye,Hanxun Zou,Lei You
标识
DOI:10.1002/cplu.202300080
摘要
The differentiation of enantiomers is of significance in synthetic chemistry and pharmaceutical chemistry. Herein, we report a facile method for chirality sensing of monoalcohols, a challenging target due to the poor reactivity, by combining dynamic covalent chemistry with helical chirality. Four diphenylethene (DPE) derived cyclic hemiaminals were constructed, and the incorporation of a broad range of alcohols and thiols with high efficiency was achieved. The reversibility was further verified by dynamic component exchange. The helical chirality of the DPE motif was induced through chirality transfer by the central chirality of the analytes, resulting in circular dichroism responses. The chirality differentiation of seven chiral secondary alcohols including both alkyl and aryl alcohols was realized, further allowing the quantification of enantiomeric excess with high accuracy. The results described should lay a foundation for future endeavors in chemical sensing, asymmetric synthesis, and chiroptical materials.
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