歧化
脱质子化
化学
铜
反应性(心理学)
催化作用
区域选择性
配体(生物化学)
金属化
吡啶甲酸
氢-氘交换
药物化学
立体化学
有机化学
氢
离子
医学
生物化学
替代医学
受体
病理
作者
Yuhang Su,Zhi‐Jiang Jiang,Jiawei Han,Lijie Duan,Jian‐Fei Bai,Jia Chen,Zhanghua Gao
标识
DOI:10.1002/chem.202403121
摘要
Despite the increasing use of copper in C‐H functionalizations, the Cu‐catalyzed direct deuteration of C‐H bonds remains a significant challenge due to its inherent low reactivity in inverse C‐H bond reconstruction. In this paper, a novel strategy had been developed to reverse the copper‐catalyzed concerted metalation‐deprotonation process by inhibiting the unexpected disproportionation of Cu(II) to Cu(III). Picolinic acid was identified as a powerful ligand for facilitating this H/D exchange with D2O as deuterium source, and its inhibition activity was supported by preliminary control experiments and DFT studies.
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