马尔科夫尼科夫法则
分子内力
催化作用
烷基化
钴
化学
阳离子聚合
氢原子
药物化学
组合化学
有机化学
烷基
区域选择性
作者
Donghao Jiang,Xinzhu Li,Mengwu Xiao,Li‐Jie Cheng
标识
DOI:10.1002/anie.202412828
摘要
A cobalt‐catalyzed intramolecular Markovnikov hydroalkoxycarbonylation and hydroaminocarbonylation of unactivated alkenes has been developed, enabling highly chemo‐ and regioselective synthesis of α‐alkylated γ‐lactones and α‐alkylated γ‐lactams in good yields. The mild reaction conditions allow use of mono‐, di‐ and trisubstituted alkenes bearing a variety of functional groups. Preliminary mechanistic studies suggest the reaction proceeds through a CO‐mediated hydrogen atom transfer (HAT) and radical‐polar crossover (RPC) process, in which a cationic acylcobalt(IV) complex is proposed as the key intermediate.
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