Inspired by Lubricin: A Tailored Cartilage–Armor with Durable Lubricity and Autophagy–activated Antioxidation for Targeted Therapy of Osteoarthritis

Osteoarthritis (OA), which disables articular cartilage, affects millions of people. The self-healing capacity is inhibited by internal oxidative stress and external lubrication deficiency and enzymatic degradation. To overcome these challenges, a tailored cartilage-armor is designed to ameliorate the inflamed cartilage, which is implemented by a novel collagen type II (Col II)-binding peptide conjugated zwitterionic polymer (PSB-