作者
Tasha Tsao,Longhui Qiu,Rashmi Bharti,Avishai Shemesh,Alberto M Hernandez,Simon J. Cleary,Nancy Y. Greenland,Jesse Santos,Rui Shi,Lu Bai,Jennifer Richardson,Kimberley Dilley,Matthias Will,Nenad Tomasevic,Tereza Sputova,Adam Salles,Ji-Hun Kang,Qian Zhang,Steven R. Hays,Jasleen Kukreja,Jonathan P. Singer,Lewis L. Lanier,Mark R. Looney,John R. Greenland,Daniel R. Calabrese
摘要
Pulmonary ischemia-reperfusion injury (IRI) is a major contributor to poor lung transplant outcomes. We recently demonstrated a central role of airway-centered NK cells in mediating IRI; however, there are no existing effective therapies for directly targeting NK cells in humans. We hypothesized that a depleting anti-CD94 monoclonal antibody (mAb) would provide therapeutic benefit in mouse and human models of IRI based on high levels of
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