胺化
化学
催化作用
均分解
功能群
反应性(心理学)
组合化学
基质(水族馆)
还原胺化
激进的
有机化学
医学
海洋学
替代医学
病理
地质学
聚合物
作者
Zhanlin Wang,Jianbo Cheng,Fei Wang
标识
DOI:10.1002/anie.202412103
摘要
7‐Aminoindoles are important synthetic intermediates to a broad range of bioactive molecules. Transition metal‐catalyzed directed C–H amination is among the most straightforward route for their synthesis, whereas methods that could directly incorporate an NH2 group in a highly selective manner remains elusive. Moreover, there is still high demand for the development of earth‐abundant metal catalysis for such attractive reactivity. We present here the first C‐7 selective NH2 amination of indoles through a directed homolytic aromatic substitution (HAS) with iron‐aminyl radical. The reaction exhibits broad substrate scope, tolerates variety of functional groups, and is readily scalable with catalyst loading down to 0.1 mol% and turnover number (TON) up to 4500.
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