Environmentally Friendly Synthesis of Highly Substituted Phenols Using Enallenoates and Grignard Reagents

We developed an efficient and environmentally friendly methodology for selectively synthesizing highly substituted phenols using readily available enallenoates and Grignard reagents. This method consistently yields good to excellent results across over 60 examples, demonstrating the substrate scope and the exploration of phenol product derivatization, further extending the method's utility.