Impacts of cationic lipid–DNA complexes on immune cells and hematopoietic cells in vivo

The cationic lipid/DNA complex significantly affects the immune and hematopoietic systems in vivo , causing leukopenia and thrombocytopenia, hematopoietic stress, and altering bone marrow cell populations by increasing long-term hematopoietic stem cells (LT-HSC) and reducing progenitor cells.