材料科学
纳米纤维
纳米颗粒
复合数
膜
静电纺丝
过氧化氢
化学工程
牙密螺旋体
纳米复合材料
纳米技术
牙龈卟啉单胞菌
牙周炎
化学
活性氧
氧气
复合材料
生物化学
有机化学
聚合物
工程类
医学
内科学
作者
Danilo Martins dos Santos,Luana Mendonça Dias,Amanda Koberstain Surur,Daniel A. de Moraes,Ana Cláudia Pavarina,Carla Raquel Fontana,Daniel S. Corrêa
出处
期刊:ACS applied nano materials
[American Chemical Society]
日期:2022-09-22
卷期号:5 (10): 14425-14436
被引量:15
标识
DOI:10.1021/acsanm.2c02774
摘要
Oxygen-generating biomaterials have the potential to improve tissue engineering and regenerative therapeutic strategies. However, the development of such materials capable of controlling the local partial pressure of oxygen (pO2) in the long term is still a major challenge. Here we report nanostructured composite membranes comprising electrospun fibers exhibiting a bead-on-string structure as a controlled oxygen-release system for periodontitis treatment. For this, calcium peroxide nanoparticles (CaO2 NPs) and manganese dioxide nanosheets (MnO2 NSs) were incorporated into the structure of hydrophobic electrospun poly (lactic acid) (PLA)-based nanofibers. We use CaO2 NPs as hydrogen peroxide (H2O2)-generating precursors when exposed to water, while MnO2 NSs were applied as a nanozyme to catalyze the decomposition of H2O2 to the final oxygen product. Our results revealed that the beads on the fibrous structure acted as reservoirs of CaO2 NPs and MnO2 NSs. Moreover, the composite membranes provided sustained oxygen release over 7 days, where levels were modulated by the CaO2 NP content. Such constructs exhibited suitable physicochemical properties and antimicrobial activities against some bacteria (e.g., Porphyromonas gingivalis and Treponema denticola) typically associated with aggressive and chronic periodontitis. In vitro studies also revealed that the membranes were not cytotoxic toward human oral keratinocyte (Nok-si) cells as well as enhanced the cell viability when high content of CaO2 NP and MnO2 NS were incorporated into the fiber's structure. Taken together, our results demonstrate that the nanostructured composite membranes show potential to be employed as oxygen-release platforms for periodontal tissue regeneration.
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