先天性淋巴细胞
效应器
生物
先天免疫系统
免疫学
免疫系统
免疫疗法
功能(生物学)
自然杀伤细胞
淋巴因子激活杀伤细胞
获得性免疫系统
自然杀伤性T细胞
细胞生物学
白细胞介素21
T细胞
细胞毒性T细胞
遗传学
体外
标识
DOI:10.1016/j.jaci.2022.09.022
摘要
Human natural killer (NK) cells are innate lymphoid cells that mediate important effector functions in the control of viral infection and malignancy. Their ability to distinguish "self" from "nonself" and lyse virally infected and tumorigenic cells through germline-encoded receptors makes them important players in maintaining human health and a powerful tool for immunotherapeutic applications and fighting disease. This review introduces our current understanding of NK cell biology, including key facets of NK cell differentiation and the acquisition and execution of NK cell effector function. Further, it addresses the clinical relevance of NK cells in both primary immunodeficiency and immunotherapy. It is intended to provide an up-to-date and comprehensive overview of this important and interesting innate immune effector cell subset.
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