Abstract P2-11-09: Excellent acute toxicity outcomes with proton therapy for partial breast irradiation in early stage breast cancer: Initial results of a multi-institutional phase II trial

医学 内科学 乳腺癌 肿瘤科 蒽环类 放射治疗 化疗 毒性 临床研究阶段 癌症 阶段(地层学) 转移性乳腺癌 三阴性乳腺癌 临床终点 质子疗法
作者
Ji Choi,AL Chang
出处
期刊:Cancer Research [American Association for Cancer Research]
卷期号:78
标识
DOI:10.1158/1538-7445.sabcs17-p2-11-09
摘要

Background and Purpose: Partial breast irradiation (PBI) with proton therapy after lumpectomy for early stage invasive breast cancer is an area of active investigation. Advantages of this technique include a shorter treatment course and the potential for decreased morbidity versus external beam photon radiation therapy given superior sparing of the surrounding normal breast tissue. To date, multiple single-institutional studies have reported conflicting results on the acute toxicity of PBI. This prospective phase II trial investigates the feasibility, safety, and efficacy of delivering PBI with proton therapy in a multi-institutional setting. Methods: Patients over the age of 50 years with ER-positive nonlobular invasive breast cancer or ductal carcinoma in situ ≤3 cm in size who had undergone lumpectomy with at least 2 mm negative surgical margins were treated with proton therapy to a dose of 40 Gy delivered over 10 daily fractions. In this initial analysis, we assess early toxicity and treatment efficacy of proton PBI. Patients were followed up at 4 weeks post-treatment and annually thereafter, along with annual mammograms. Patient-reported quality of life and physician-reported cosmesis assessments including photographs were obtained at 1 and 3 years post-treatment. Results: Forty patients were enrolled, of which 38 were evaluable. At a median follow-up of 17.8 months (range 2-36 months), all patients had overall breast cosmesis that was scored “good” or “excellent”. Of 6 grade 2 acute adverse events that occurred, only 1 was radiation dermatitis, with others including lymphedema, hot flashes, and fatigue. One grade 3 acute toxicity occurred 3 weeks after radiation completion in the form of vascular disease requiring stent placement, highly unlikely to be attributable to radiation effects. Patient-reported quality of life outcomes were recorded using the standardized Breast Cancer Treatment Outcome Scale (BCTOS) scored from 1-4 (1: none; 2: mild; 3: moderate; 4: large), with endpoints receiving a score of 3 or 4 most frequently involving change in breast size, breast texture, nipple appearance, or scar tissue. Patients assigned a score of 4 for change in nipple appearance (n=2), breast shape (n=2), and scar tissue formation (n=2). To date, local, locoregional, and distant disease control are 100%, although one patient has developed a new hormone receptor-negative invasive ductal carcinoma of the contralateral breast. Conclusion: Proton PBI provides excellent early cancer control with acceptable cosmetic outcomes and minimal adverse effects as per patient- and physician-reported assessments. On continued follow-up, late toxicity and cosmesis, as well as long-term disease control outcomes, will be assessed. Citation Format: Choi JI, Chang AL. Excellent acute toxicity outcomes with proton therapy for partial breast irradiation in early stage breast cancer: Initial results of a multi-institutional phase II trial [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr P2-11-09.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
YCu完成签到 ,获得积分10
2秒前
zehua309完成签到,获得积分10
2秒前
玥瑶发布了新的文献求助20
2秒前
青鱼完成签到,获得积分10
3秒前
fosca完成签到,获得积分10
4秒前
Loststar完成签到,获得积分20
5秒前
11完成签到 ,获得积分10
6秒前
Yi完成签到,获得积分10
7秒前
糊辣鱼完成签到 ,获得积分10
9秒前
科研韭菜完成签到 ,获得积分10
9秒前
我有一个梦想完成签到,获得积分10
10秒前
宫跃然完成签到,获得积分10
11秒前
Holybot完成签到,获得积分10
12秒前
潇湘阁我爱吃完成签到,获得积分10
13秒前
十三应助科研通管家采纳,获得10
15秒前
科奇应助科研通管家采纳,获得10
15秒前
顺心紫南完成签到,获得积分10
15秒前
15秒前
chi完成签到 ,获得积分10
17秒前
花花猪1989完成签到,获得积分10
17秒前
暖暖的禾日完成签到,获得积分10
19秒前
XL神放完成签到 ,获得积分10
19秒前
为妳铭记完成签到 ,获得积分10
20秒前
21秒前
LUCKY完成签到 ,获得积分10
21秒前
fy完成签到,获得积分10
23秒前
牵绊完成签到 ,获得积分10
24秒前
好名字完成签到,获得积分10
24秒前
张龙雨完成签到,获得积分10
24秒前
清秀凡霜完成签到,获得积分10
27秒前
15122303完成签到,获得积分10
28秒前
ioio完成签到 ,获得积分10
28秒前
HuanChen完成签到,获得积分10
30秒前
wang完成签到,获得积分10
30秒前
默默的巧蕊完成签到,获得积分10
30秒前
陈怼怼完成签到,获得积分10
32秒前
33秒前
KaiZI完成签到 ,获得积分10
34秒前
皮PP完成签到,获得积分10
34秒前
strama完成签到,获得积分10
35秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968578
求助须知:如何正确求助?哪些是违规求助? 3513406
关于积分的说明 11167631
捐赠科研通 3248853
什么是DOI,文献DOI怎么找? 1794499
邀请新用户注册赠送积分活动 875150
科研通“疑难数据库(出版商)”最低求助积分说明 804671