重症监护医学
立场文件
医学
临床试验
败血症
梅德林
精密医学
临床研究设计
抗菌管理
个性化医疗
生物信息学
抗生素
免疫学
病理
抗生素耐药性
生物
微生物学
生物化学
作者
Jordi Rello,R van Engelen Tjitske S,Emine Alp,Thierry Calandra,Vincent Cattoir,V Kern Winfried,G. Netea Mihai,Saad Nseir,M Opal Steven,Frank L. van de Veerdonk,Harriet Mark,W. Joost Wiersinga
标识
DOI:10.1016/j.cmi.2018.03.011
摘要
Our current understanding of the pathophysiology and management of sepsis is associated with a lack of progress in clinical trials, which partly reflects insufficient appreciation of the heterogeneity of this syndrome. Consequently, more patient-specific approaches to treatment should be explored.To summarize the current evidence on precision medicine in sepsis, with an emphasis on translation from theory to clinical practice. A secondary objective is to develop a framework enclosing recommendations on management and priorities for further research.A global search strategy was performed in the MEDLINE database through the PubMed search engine (last search December 2017). No restrictions of study design, time, or language were imposed.The focus of this Position Paper is on the interplay between therapies, pathogens, and the host. Regarding the pathogen, microbiologic diagnostic approaches (such as blood cultures (BCs) and rapid diagnostic tests (RDTs)) are discussed, as well as targeted antibiotic treatment. Other topics include the disruption of host immune system and the use of biomarkers in sepsis management, patient stratification, and future clinical trial design. Lastly, personalized antibiotic treatment and stewardship are addressed (Fig. 1).A road map provides recommendations and future perspectives. RDTs and identifying drug-response phenotypes are clear challenges. The next step will be the implementation of precision medicine to sepsis management, based on theranostic methodology. This highly individualized approach will be essential for the design of novel clinical trials and improvement of care pathways.
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