已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Is cryptogenic cirrhosis different from NASH cirrhosis?

肝硬化 医学 内科学 胃肠病学 脂肪性肝炎 肝细胞癌 脂肪肝 酒精性肝病 肝病 肥胖 乙型肝炎 疾病
作者
Paul J. Thuluvath,Sergey V. Kantsevoy,Avesh J. Thuluvath,Yulia Savva
出处
期刊:Journal of Hepatology [Elsevier]
卷期号:68 (3): 519-525 被引量:56
标识
DOI:10.1016/j.jhep.2017.11.018
摘要

We hypothesized that patients currently diagnosed with cryptogenic cirrhosis (CC) have truly 'cryptogenic' liver disease, which is unlikely to have evolved from NASH. The aim of this study is to characterize patients with CC, and compare their characteristics to patients with cirrhosis of other etiologies.To investigate this, we compared the clinical characteristics of adults with CC (n = 7,999) to those with cirrhosis caused by non-alcoholic steatohepatitis (NASH) (n = 11,302), alcohol (n = 21,714) and autoimmune hepatitis (n = 3,447), using the UNOS database from 2002-16. We performed an age, gender and year of listing matched comparison of CC and NASH (n = 7,201 in each group), and also stratified patients by the presence of obesity or diabetes mellitus (DM).From 2002 to 2016, patients listed with a diagnosis of NASH increased from about 1% to 16% while CC decreased from 8% to 4%. A logistic regression model using the entire United Network for Organ Sharing data (n = 138,021) suggested that the strongest predictors of NASH were type 2 DM, obesity, age ≥60 years, female gender and white race. Type 2 DM was more common in patients with NASH (53%) than those with CC (29%), alcoholic cirrhosis (16%) and autoimmune hepatitis (16%), and obesity was more common in NASH (65.3%) compared to the other three groups (33-42%). There were more white individuals (82.3%) in the NASH group and a lower prevalence of black, Hispanic and Asian individuals, compared to the other three groups. Hepatocellular carcinoma was more commonly seen in NASH (19% vs. 9-13% in the other groups) and this is not influenced by obesity and type 2 DM. The differences between CC and NASH remained unchanged even when two groups were matched for age, gender and year of listing, or when stratified by the presence or absence of obesity or type 2DM.Based on risk perspectives, CC should not be equated with the term 'NASH cirrhosis'.We hypothesized that cryptogenic cirrhosis is a distinct condition from cirrhosis caused by non-alcoholic steatohepatitis (NASH). By comparing cryptogenic cirrhosis with cirrhosis of other causes, we found clear clinical differences. Therefore, cryptogenic cirrhosis should not be considered the same as NASH cirrhosis. Further investigations are required to identify unknown causes of cirrhosis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
温柔的刀发布了新的文献求助10
4秒前
爱因斯坦完成签到,获得积分20
6秒前
貔貅完成签到,获得积分10
6秒前
7秒前
10秒前
CornellRong发布了新的文献求助10
13秒前
SciGPT应助GEYUAN采纳,获得10
15秒前
ding应助科研通管家采纳,获得10
18秒前
在水一方应助科研通管家采纳,获得10
18秒前
18秒前
18秒前
温柔的刀完成签到,获得积分10
22秒前
loxife关注了科研通微信公众号
23秒前
25秒前
元问晴完成签到,获得积分10
25秒前
爱因斯坦发布了新的文献求助30
26秒前
26秒前
元友容完成签到 ,获得积分10
27秒前
yoga完成签到 ,获得积分10
29秒前
30秒前
Hayat发布了新的文献求助10
31秒前
kasdf发布了新的文献求助10
33秒前
落寞代亦发布了新的文献求助10
34秒前
34秒前
xiaoyaoswim发布了新的文献求助50
38秒前
Orange应助allen采纳,获得10
40秒前
40秒前
111完成签到 ,获得积分10
40秒前
loxife发布了新的文献求助10
42秒前
42秒前
儒雅的绿兰完成签到 ,获得积分10
43秒前
甜田完成签到 ,获得积分10
45秒前
任性大米完成签到 ,获得积分10
45秒前
46秒前
彭于晏应助tkdzjr12345采纳,获得10
50秒前
欲目完成签到 ,获得积分10
53秒前
今后应助碧蓝板栗采纳,获得20
55秒前
55秒前
tkdzjr12345发布了新的文献求助10
1分钟前
1分钟前
高分求助中
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger Heßler, Claudia, Rud 1000
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 1000
Natural History of Mantodea 螳螂的自然史 1000
A Photographic Guide to Mantis of China 常见螳螂野外识别手册 800
Autoregulatory progressive resistance exercise: linear versus a velocity-based flexible model 500
Spatial Political Economy: Uneven Development and the Production of Nature in Chile 400
Research on managing groups and teams 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 细胞生物学 免疫学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3330292
求助须知:如何正确求助?哪些是违规求助? 2959850
关于积分的说明 8597590
捐赠科研通 2638395
什么是DOI,文献DOI怎么找? 1444345
科研通“疑难数据库(出版商)”最低求助积分说明 669096
邀请新用户注册赠送积分活动 656633