Neuro-immune cell cross-talk

Neuroimmunology An emerging mechanism of tissue homeostasis involves cross-talk between neuronal and immune cells. In a Perspective, Veiga-Fernandes and Artis discuss how neuronal and immune cells can jointly coordinate gross tissue immune responses, particularly at barrier tissues such as the intestinal and lung epithelia. They describe how neuronal cells regulate immune cells at these sites and ask whether immune cells can, in turn, regulate neuronal cells. Furthermore, the authors describe the implications of this cross-talk for diseases including chronic inflammation, cancer, and metabolic syndrome. Science , this issue p. [1465][1] [1]: /lookup/doi/10.1126/science.aap9598