Recent research suggests that impaired emotion regulation (ER) may play an important role in the development of youth psychopathology. However, little research has explored the effects of ER strategies on affect in early adolescents. In Study 1 (n = 76), we examined if early adolescents are able to use distraction and whether the effects of this strategy are similar to talking to one's mother. In Study 2 (n = 184), we compared the effects of distraction, cognitive reappraisal, acceptance, and rumination. In both studies, participants received instructions on how to regulate their emotions after a standardised negative mood induction. In general, the results indicated that distraction, but also cognitive reappraisal and acceptance, had promising short-term effects on positive and negative affect in early adolescents. These findings suggest that targeting adaptive ER skills, such as distraction, acceptance, and cognitive reappraisal, may be an important strategy to prevent or treat psychological problems in early adolescents.