Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial Biogenesis

(Cell Metabolism 31, 174–188.e1–e7; January 7, 2020) In the original version of the paper, the surname of Dr. Simon was mistakenly written as “Celeste Simon.” This error has now been corrected online. Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial BiogenesisHuangyang et al.Cell MetabolismNovember 21, 2019In BriefHuangyang et al. demonstrate that the loss of fructose-1,6-bisphosphatase 2 (FBP2) is a common metabolic feature of soft tissue sarcomas (STSs). Restoration of FBP2 in STS cells suppresses sarcoma growth through two mechanisms, including inhibiting glycolysis and restraining mitochondrial biogenesis by inhibiting c-Myc-driven transcriptional activity. Full-Text PDF Open Archive