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Assessing Mild Cognitive Impairment in Parkinson’s Disease by Magnetic Resonance Quantitative Susceptibility Mapping Combined Voxel-Wise and Radiomic Analysis

壳核 蒙特利尔认知评估 苍白球 帕金森病 黑质 尾状核 海马体 红核 定量磁化率图 心理学 磁共振成像 医学 内科学 神经科学 认知 中枢神经系统 基底神经节 认知障碍 疾病 放射科 核心
作者
Yi Zhao,Hang Qu,Wei Wang,Jiangbing Liu,Yu Pan,Zheng Li,Gang Xu,Chunhong Hu
出处
期刊:European Neurology [Karger Publishers]
卷期号:85 (4): 280-290 被引量:9
标识
DOI:10.1159/000522329
摘要

The relationship between iron accumulation in the central nervous system and cognitive decline in Parkinson's disease (PD) has not been fully elucidated. This study aimed to explore the value of quantitative susceptibility mapping in assessment of mild cognitive impairment (MCI) in PD.Sixteen PD patients with MCI (PD-MCI), sixteen normal cognition PD patients (PD-NC), and 28 healthy controls (HCs) were included. The differences in the magnetic susceptibility and Radiomic indicators among groups and their correlations with Montreal Cognitive Assessment-Basic (MoCA-B) scores and Unified Parkinson's Disease Rating Scale Part III (UPDRS-III) were analyzed. Receiver operating characteristic curves were used to evaluate the diagnostic performance.Higher iron deposition was observed in the cortical and subcortical structures of the PD patients compared with HCs, including limbic system, orbitofrontal cortex, cuneus, red nucleus, and substantia nigra. Combined magnetic susceptibility and texture index in hippocampus achieved the best diagnostic performance (area under curves: 0.828) in differentiating PD-MCI from PD-NC. The magnetic susceptibilities of the substantia nigra, red nucleus, putamen, globus pallidus, hippocampus, and thalamus were negatively correlated with the MoCA-B scores (all p < 0.05), and of the putamen and amygdala were positively correlated with the UPDRS-III scores (both p < 0.05).Higher iron deposition was observed in the cortical and subcortical structures of the PD-MCI and PD-NC groups. The susceptibility values of vulnerable brain subregions shown significant correlation with MoCA-B and UPDRS-III. Together with the texture index, magnetic susceptibility values could provide robust performance in distinguishing PD-MCI patients from PD-NC.
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