医学
荟萃分析
全身炎症反应综合征
内科学
败血症
科克伦图书馆
接收机工作特性
预警得分
梅德林
急诊医学
政治学
法学
作者
Can Wang,Rufu Xu,Yuerong Zeng,Yu Zhao,Xuelian Hu
出处
期刊:PLOS ONE
[Public Library of Science]
日期:2022-04-15
卷期号:17 (4): e0266755-e0266755
被引量:8
标识
DOI:10.1371/journal.pone.0266755
摘要
Objective To identify and compare prognostic accuracy of quick Sequential Organ Failure Assessment (qSOFA) score, Systemic Inflammatory Response Syndrome (SIRS) criteria, and National Early Warning Score (NEWS) to predict mortality in patients with suspected sepsis. Methods This meta-analysis followed accordance with the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. We searched PubMed, EMBASE, Web of Science, and the Cochrane Library databases from establishment of the database to November 29, 2021. The pooled sensitivity and specificity with 95% CIs were calculated using a bivariate random-effects model (BRM). Hierarchical summary receiver operating characteristic (HSROC) curves were generated to assess the overall prognostic accuracy. Results Data of 62338 patients from 26 studies were included in this meta-analysis. qSOFA had the highest specificity and the lowest sensitivity with a specificity of 0.82 (95% CI: 0.76–0.86) and a sensitivity of 0.46 (95% CI: 0.39–0.53). SIRS had the highest sensitivity and the lowest specificity with a sensitivity of 0.82 (95% CI: 0.78–0.85) and a specificity 0.24 (95% CI: 0.19–0.29). NEWS had both an intermediate sensitivity and specificity with a sensitivity of 0.73 (95% CI: 0.63–0.81) and a specificity 0.52 (95% CI: 0.39–0.65). qSOFA showed higher overall prognostic accuracy than SIRS and NEWS by comparing HSROC curves. Conclusions Among qSOFA, SIRS and NEWS, qSOFA showed higher overall prognostic accuracy than SIRS and NEWS. However, no scoring system has both high sensitivity and specificity for predicting the accuracy of mortality in patients with suspected sepsis.
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