Sphingosine 1-phosphate and its regulatory role in vascular endothelial cells.

1-磷酸鞘氨醇 鞘氨醇 S1PR1型 鞘氨醇激酶1 血管生成 内皮 内皮干细胞 生物 细胞生物学 鞘氨醇-1-磷酸受体 鞘氨醇激酶 医学 癌症研究 血管生成
作者
Yan Qiu,Junyi Shen,Wenli Jiang,Yi Yang,Xiaoheng Liu,Ye Zeng
出处
期刊:Histology and Histopathology 卷期号:: 18428-18428
标识
DOI:10.14670/hh-18-428
摘要

Sphingosine 1-phosphate (S1P) is a bioactive metabolite of sphingomyelin. S1P activates a series of signaling cascades by acting on its receptors S1PR1-3 on endothelial cells (ECs), which plays an important role in endothelial barrier maintenance, anti-inflammation, antioxidant and angiogenesis, and thus is considered as a potential therapeutic biomarker for ischemic stroke, sepsis, idiopathic pulmonary fibrosis, cancers, type 2 diabetes and cardiovascular diseases. We presently review the levels of S1P in those vascular and vascular-related diseases. Plasma S1P levels were reduced in various inflammation-related diseases such as atherosclerosis and sepsis, but were increased in other diseases including type 2 diabetes, neurodegeneration, cerebrovascular damages such as acute ischemic stroke, Alzheimer's disease, vascular dementia, angina, heart failure, idiopathic pulmonary fibrosis, community-acquired pneumonia, and hepatocellular carcinoma. Then, we highlighted the molecular mechanism by which S1P regulated EC biology including vascular development and angiogenesis, inflammation, permeability, and production of reactive oxygen species (ROS), nitric oxide (NO) and hydrogen sulfide (H2S), which might provide new ways for exploring the pathogenesis and implementing individualized therapy strategies for those diseases.
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