反离子
离子交换
化学
范围(计算机科学)
离子交换树脂
离子
聚合物
表征(材料科学)
组合化学
有机化学
纳米技术
材料科学
计算机科学
程序设计语言
作者
Tianyi Zhang,Ruofei Du,Youjie Wang,Jialiang Hu,Fei Wu,Yi Feng
出处
期刊:Aaps Pharmscitech
[Springer Nature]
日期:2022-04-05
卷期号:23 (4)
被引量:11
标识
DOI:10.1208/s12249-022-02260-6
摘要
As insoluble polymer materials, ion-exchange resins (IERs) can exchange their own ions with desirable charged ions in the solution. According to the affinity of active moieties for soluble counterions, IERs could be categorized into the following four types: strongly acidic cation, weakly acidic cation, strongly basic anion, and weakly basic anion exchange resins. Due to their relative safety and high drug-loading capacity, IERs have garnered extensive attention in the pharmaceutical field since the 1950s. As numerous investigations combine drugs with IERs, this article summarizes the technologies employed in these studies from four aspects: IER screening principles, combining technologies, characterization methods, and in vitro and in vivo release of drug-resinate complexes. In addition, the advantages and disadvantages of various technologies and their scope are expounded. The article provides new insights on the preparation of ion-exchange resin complexes.
科研通智能强力驱动
Strongly Powered by AbleSci AI