微生态学
炎症性肠病
免疫系统
疾病
肠道菌群
势垒函数
免疫学
炎症
细菌
微生物学
医学
生物
细胞生物学
病理
遗传学
作者
Qichen Shen,Bingbai Xu,Caihong Wang,Yingping Xiao,Yuanxiang Jin
出处
期刊:Life Sciences
[Elsevier BV]
日期:2022-07-15
卷期号:306: 120803-120803
被引量:13
标识
DOI:10.1016/j.lfs.2022.120803
摘要
Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation with no cure. The intestine is fundamental in controlling human health. Disruption of the microbial ecosystem in the intestine is considered an important cause of IBD. The interaction between the host and microbiota significantly impacts the intestinal epithelial barrier and immune function. Bacterial membrane vesicles (MVs) are vital participants in bacteria-bacteria and host-microbiota communication. Currently, MVs have been found to exhibit many important regulating effects for intestinal microecology and have excellent application potential in clinical disease therapies. In the present review, we review the current knowledge on MVs, and specifically focus on gut bacterial MVs and their roles in the IBD. In addition, we summarized the potential utility of MVs as a novel therapeutic approach in IBD patients.
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