Association of cytokine profile with prior treatment failure and revision surgery in chronic rhinosinusitis

医学 细胞因子 慢性鼻-鼻窦炎 内科学 鼻窦炎 外科 联想(心理学) 认识论 哲学
作者
Elizabeth S. Longino,Alex B. Labby,Jeffanie Wu,Nikita Chapurin,Ping Li,Rakesh K. Chandra,Justin H. Turner,Naweed I. Chowdhury
出处
期刊:International Forum of Allergy & Rhinology [Wiley]
卷期号:13 (1): 5-14 被引量:12
标识
DOI:10.1002/alr.23035
摘要

Inflammatory patterns in chronic rhinosinusitis (CRS) may predict disease severity, need for multiple sinus surgeries, and treatment response. This study analyzes nasal mucus inflammatory cytokine patterns in patients with (CRSwNP) and without (CRSsNP) nasal polyposis and their association with revision sinus surgery.A total of 319 CRS patients who underwent sinus surgery were included. Cytokines were quantified in intraoperative mucus specimens using a multiplex flow cytometric bead assay. Cytokine expression patterns in patients with 0, 1, and ≥2 previous surgeries were analyzed using Kruskal-Wallis and principal component (PC) regression analyses.There were 122 (38%) patients with CRSsNP and 197 (62%) with CRSwNP. On univariate analysis, interleukin (IL)-1β, IL-6, IL-8, and IL-21 were associated with increasing number of sinus surgeries in CRSsNP, as were IL-2, IL-4, IL-5, IL-6, IL-9, IL-17A, and tumor necrosis factor (TNF)-α in CRSwNP. PC analysis with continuous Poisson regression in CRSwNP demonstrated that high IL-5 and IL-13 and low IL-1β, IL-12, and IL-21 were associated with more prior surgeries. In CRSsNP low IL-13 and high IL-5 and regulated-on-activation, normal T-cell-expressed and secreted (RANTES) were associated with more prior surgeries. Age remained a significant covariate in the full regression model for CRSsNP, but was nonsignificant in CRSwNP.In CRSwNP, elevated IL-5 and IL-13 levels were higher at time of surgery in patients with more prior surgeries. Type 2 cytokines in CRSsNP demonstrated mixed associations with revision surgery. For both phenotypes, IL-10, IL-12, and IL-21 were consistently lower as number of prior surgeries increased, suggesting that treatment-resistant disease may be modulated by impairment in these signaling pathways.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
852应助芬栀采纳,获得10
刚刚
1秒前
jiangmj1990发布了新的文献求助10
1秒前
2秒前
赵医生发布了新的文献求助10
2秒前
Xian发布了新的文献求助10
3秒前
干净的寒天发布了新的文献求助200
4秒前
SaiKerry发布了新的文献求助10
4秒前
大喵发布了新的文献求助10
5秒前
wanci应助一颗椰子糖耶采纳,获得10
5秒前
5秒前
忐忑的成仁完成签到,获得积分10
7秒前
乐乐应助_Y_X_L_采纳,获得10
7秒前
7秒前
星辰大海应助漂亮白枫采纳,获得10
11秒前
i3utter发布了新的文献求助10
11秒前
Rondab应助momo采纳,获得10
11秒前
FashionBoy应助大喵采纳,获得10
15秒前
他克莫司发布了新的文献求助100
16秒前
17秒前
17秒前
17秒前
18秒前
赘婿应助zoey采纳,获得10
19秒前
21秒前
烟花应助TT木木采纳,获得10
21秒前
SciGPT应助健忘的水蜜桃采纳,获得10
22秒前
小刘发布了新的文献求助10
23秒前
一直向前发布了新的文献求助10
23秒前
精明怜南发布了新的文献求助10
23秒前
24秒前
李健的粉丝团团长应助11采纳,获得10
24秒前
_Y_X_L_发布了新的文献求助10
25秒前
26秒前
26秒前
图图完成签到 ,获得积分10
26秒前
27秒前
行者完成签到,获得积分10
27秒前
恋雅颖月应助陈桉采纳,获得10
29秒前
29秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989797
求助须知:如何正确求助?哪些是违规求助? 3531914
关于积分的说明 11255516
捐赠科研通 3270597
什么是DOI,文献DOI怎么找? 1805008
邀请新用户注册赠送积分活动 882181
科研通“疑难数据库(出版商)”最低求助积分说明 809190