An 18-year-old woman presented with a 6-mm dentoalveolar open bite, Class II molar malocclusion, deviated midline in both arches, slight crowding, labial inclination of the maxillary incisors, and lingual inclination of the mandibular incisors. The patient was treated with clear aligners to correct the anterior open bite and reduce the lower facial height. The results showed that clear aligners could effectively correct severe anterior open bite. The treatment was completed in 22 months, and the patient was satisfied with the esthetics and function.