异丙酚
医学
CYP2C9
结肠镜检查
药代动力学
麻醉
单核苷酸多态性
镇静
血压
药物遗传学
基因型
胃肠病学
内科学
作者
Mara Aparecida Maricato Poma,Howard Lopes Ribeiro Junior,Eugênio Araújo Costa,Carlos Roberto Koscky Paier,Laís Lacerda Brasil,Luína Benevides Lima,Livia Maria Soares Nobre,Tayales Tavares Leite,Roberto César Pereira Lima-Júnior,Ana Rosa Pinto Quidute,Maria Elisabete Amaral de Moraes,Manoel Odorico de Moraes Filho
标识
DOI:10.1136/postgradmedj-2021-141375
摘要
The aim of this study was to investigate the effect of CYB2B6 (c.516G>T, rs3745274), CYP2C9 (c.1075A>C, rs1057910) and UGT1A9 (c.98T>C, rs72551330) polymorphisms on the pharmacokinetics of single-drug propofol in adult patients undergoing intravenous sedation.In this prospective clinical study, a total of 124 patients undergoing anaesthesia with propofol, as a single drug, were evaluated when undergoing colonoscopy procedure. Clinical variables were obtained from the patient's anamnesis prior to performing the anaesthetic procedure, in the moment of the patient's loss of consciousness, during the colonoscopy exam (recorded every 5 min) and in the awakening time.Polymorphic genotypes for the rs3745274 and rs1057910 polymorphisms were associated with bispectral index, target-controlled infusion (TCI)/effector concentration of propofol and TCI/plasma concentration of propofol values. Based on multivariate analysis, it was observed that weight, age, surgery time, systolic blood pressure and the rs1057910 polymorphism corresponded to predictive values for the dose of propofol used. Weight (B=4.807±0.897), age (B=1.834±0.834) and duration of surgery (B=8.164±1.624) corresponded to factors associated with increased propofol dose, while systolic blood pressure (B=-1.892±0.679) and the genotypes (AA vs CA) of the single nucleotide polymorphism (SNP) rs1057910 CYPP2C9 gene (B=-74.161±26.820) decreased the total dose of propofol used.We concluded that the rs1057910 and rs3745274 polymorphisms affect the metabolism of propofol in patients exclusively submitted to this drug. Thus, the knowledge of the polymorphic genotypes of the CYPP2C9 and CYB2B6 genes may be predictive of different metabolising phenotypes, suggesting expected behaviours of BIS parameter in the anaesthetic procedure, which contributes to safer monitoring by anaesthesiologists during the clinical intervention.
科研通智能强力驱动
Strongly Powered by AbleSci AI