Glutathione-responsive multifunctional nanoparticles based on mannose-modified pillar[5]arene for targeted antibiotic delivery against intracellular methicillin-resistant S. aureus

GSH-responsive multifunctional antibiotic delivery system (WP5⊃G) was successfully developed. WP5⊃G could encapsulate linezolid (LZD) to form drug-loaded nanoparticles (LZD-WP5⊃G), improving the anti-intracellular MRSA activity of LZD with excellent biocompatibility.