Higher Systemic Immune-Inflammation Index is Associated With Higher Likelihood of Peripheral Arterial Disease

To explore the association between SII (Systemic Immune-Inflammation Index) and PAD (peripheral arterial disease) in American adults.Related data from NHANES (National Health and Nutrition Examination Survey) database (1999-2004) were collected and analyzed. PAD was diagnosed by ankle brachial index assessment. The association between SII and prevalent PAD was assessed using multivariable logistic regression.A total of 6,576 eligible subjects (including 6117 subjects without PAD and 459 with PAD) were finally enrolled in the study, among which there were 3,187 females and 3,389 males with a mean SII of 585.3 ± 401.5. The age of the subjects with PAD was larger compared to those without PAD (70.2 ± 11.8 vs. 58.7 ± 12.5), and the incidence of chronic diseases, that's CAD, diabetes and hypertension, was higher in those without PAD (P < 0.001). Multivariable logistic regression indicated that a high SII level was an independent risk factor for PAD (OR = 1.51, 95% CI: 1.18- 1.93, P = 0.0012) after adjusting for body mass index, race, sex, age, diabetes mellitus (yes/no), hypertension (yes/no), and cardiovascular disease (yes/no).It is suggested that a higher SII is associated with a higher risk of PAD.