Palladium-catalyzed enantioselective C–H functionalization via C–H palladation

Enantioselective C–H functionalization has emerged as a powerful and straightforward strategy to construct chiral molecules. Compared with other transition-metal catalysts, palladium is particularly attractive as a catalyst for enantioselective C–H functionalization due to its high reactivity, incredible versatility, and good functional group tolerance. The discovery of novel chiral ligands with high catalytic activity, simple structure, and modular synthesis would offer exciting opportunities for enantioselective C–H functionalization. Transition-metal-catalyzed enantioselective C–H bond activation has emerged as an increasingly important tool for the expedient synthesis of complex chiral molecules. In the past decade, palladium, one of the most commonly employed metal catalysts, has attracted significant attention in enantioselective C–H functionalization for its great promise to streamline the synthesis of chiral molecules and inspired new retrosynthetic disconnections. This review highlights recent advances in Pd-catalyzed enantioselective C–H functionalization reactions with an emphasis on the catalytic pathways, types of chiral ligands, and chirality. Transition-metal-catalyzed enantioselective C–H bond activation has emerged as an increasingly important tool for the expedient synthesis of complex chiral molecules. In the past decade, palladium, one of the most commonly employed metal catalysts, has attracted significant attention in enantioselective C–H functionalization for its great promise to streamline the synthesis of chiral molecules and inspired new retrosynthetic disconnections. This review highlights recent advances in Pd-catalyzed enantioselective C–H functionalization reactions with an emphasis on the catalytic pathways, types of chiral ligands, and chirality. the process of converting the carbon–hydrogen bond into a weaker carbon–metal bond. the metal/base-promoted C–H bond cleavage that occurs by a simultaneous metalation and deprotonation processes. the process by which an alkyl group that is bonded to a metal center and has a hydrogen atom attached to the metal center can be converted into an alkene and a metal hydride. the reverse of reductive elimination. A process by which a metal inserts into a covalent bond and formally increases its oxidation state by two. an elementary organometallic step in which a new covalent bond is formed between two ligands, and the metal formally decreases its oxidation state by two. transfer of ligands from one metal center to another.